文章基本信息

标题：The Role of Alpha-1 Antitrypsin Enzyme on Pulmonary DysfunctionDue to Exposure to NO2
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作者：Satria Pratama ; Satria Pratama ; Bambang Wispriyono 等
期刊名称：Research Journal of Applied Sciences
印刷版ISSN：1815-932X
电子版ISSN：1993-6079
出版年度：2018
卷号：13
期号：4
页码：229-234
DOI：10.3923/rjasci.2018.229.234
语种：English
出版社：Medwell Journals
摘要：Nitrogen dioxide (NO2) is one of the air pollutants whose concentration is increasing due to the increased number of vehicles as a mode of transportation. Exposure to NO2 causes physical symptoms ofrespiratory disorders and lung function and Alpha 1 Antitrypsin (AAT) plays a role in the protection ofinflammation due to exposure to NO2 through inactivation by nitrogen. This study aims to reveal the relationship of NO2 exposure, AAT and lung function of the traffic police in Jakarta. It is a cross sectional study with 112 traffic police as research subjects divided into two groups: the police working on the highway andworking in the office. NO2 measurement of the environment is carried out at the location where the subjects work and examination is done toward lung physiology, AAT levels, body weight, body fat percentage, heightand waist circumference as a factor in determining lung function. NO2 levels are 18.72 ppb on highways (high exposure areas) and 4.14 ppb in the office (low exposure area), respectively. There are 49% of the traffic policeworking on the highway (high exposure to NO2 ) and 51% of police officers working in the office (low exposure to NO2 ). Mean of pulmonary physiology, represented by percentage of FVC (Forced Vital Capacity), on the entire subject is 89.49 and mean of FEV1 (Forced Expiratory Volume in 1 sec) is 95.39. The mean of FEV1compared to FVC is 88.4 and there is no significant difference between police officers working in the highwayand working in the office. AAT levels in both subjects show normal values compared to normal levels of AATstandard of 141.07 mg/dL. Finally, the prediction model obtained in the end which is the prediction of FVCpercentage and FEV1 percentage for both the dependent variable has a normal distribution. In conclusion, thevalue of lung function for police officers working on the roads is lower than the value of lung function of thoseworking in the office. Factors that affect lung function in this study are NO2 levels, AAT, fat, age (35 years old), visceral fat and waist circumference.
关键词：NO2;AAT;FEV1;FVC;traffic police;Jakarta;Indonesia