文章基本信息

标题：Exercise, Nitric Oxide, and Endothelial Dysfunction: A Brief Review
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作者：Ricardo Yukio Asano ; Ricardo Yukio Asano ; Marcelo Magalhães Sales 等
期刊名称：Journal of exercise physiology online
印刷版ISSN：1097-9751
出版年度：2012
卷号：15
期号：1
页码：76-86
语种：English
出版社：American Society of Exercise Physiologists
摘要：Asano RY, Sales MM, Coelho JMO, Moraes JFVN, Pereira LA, Simões HG. Exercise, Nitric Oxide, and Endothelial Dysfunction: A Brief Review. JEPonline 2012;15(1):76-86. Nitric oxide (NO) is biosynthesized from the amino acid L-arginine, oxygen, and a variety of co-factors mediated by nitric oxide synthase (e-NOS). Nitric oxide is referenced as a relaxing factor in the endothelium, acting as a potent vasodilator that plays an important role in controlling vascular tone. Studies have demonstrated the role of NO in preserving the functional capacity of the endothelium, preventing atherosclerosis, vascular injury, and hypertension. Moreover, genotypic and/or phenotypic factors may adversely influence the bioavailability of NO, resulting in severe endothelial dysfunction and increased peripheral vascular resistance. Studies have shown exercise as an effective intervention to increase the bioavailability of NO acutely and chronically, for exercise may provide improvement in musculoskeletal and circulatory systems by increasing local blood flow and, therefore, preventing illness or increase performance. Thus, the purpose of this brief review was to elucidate the molecular mechanisms involved in the synthesis and regulation of NO, demonstrating the advances of scientific knowledge related to its bioavailability mediated by exercise and the impact of this phenomenon on endothelial dysfunction. To achieve this objective, we reviewed the scientific literature published in the following databases: Scielo, Medline, Pubmed, WebScience, SCOPUS and SportDiscuss (EBSCO), using the keywords: “nitric oxide” and “exercise.”
关键词：Nitric Oxide;Exercise;Endothelial Dysfunction