摘要:Fabri T, Machado KB, Rezende RS, Mercês L, Vieira MAR, Campagnole-Santos MJ, Rocha-Vieira E, Becker LK. Aquatic And Land Exercise Training Affects Renal Function In Rats Under Isosmotic Volume Expansion. JEPonline 2010;13(2):42-51. Water immersion has been associated with modulation of the cardiac-renal axis because it induces effects such as diuresis and natriuresis. However, studies targeting the effects of aquatic exercise training on renal function are lacking. In this study, we compared the effects of aquatic (AE) and land exercise (LE) training on the renal function of rats at rest and after plasma isosmotic volume expansion. Rats were trained daily for 60 min/day over a six-week period. The effects of training on renal function at rest and after volume expansion were measured in rats individually housed in metabolic cages for 24 and 3 h, respectively. In the latter, the rats were volume expanded with 0.9% NaCl (6% of body weight, by gavage). At rest, the urine volume (ml/24 h) was higher in both AE (23±2) and LE rats (18±3) than in sedentary rats (10±2). The urine osmolality (mOsm/kg) of AE (680±100) and LE (1260±210) rats was lower than that of the sedentary animals (2240±500). In addition, AE exhibited the highest urine production after acute expansion. After 3 h of volume expansion, the urine volume (ml) was 8.2±1.6 in AE animals, while in sedentary and LE rats the urine volumes were 5.4±2.4 and 6.6±3.3, respectively. Similarly, after volume expansion, the urinary sodium excretion was higher in the AE rats than in the sedentary and LE rats. Our data suggest that aquatic exercise may greatly improve renal function.