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标题：Response of Creatine Kinase (CK) Levels in Diabetics Wistar Rats After Acute Physical Exercise
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作者：Marcelo Costa Junior ; Marcelo Costa Junior ; Alex 等
期刊名称：Journal of exercise physiology online
印刷版ISSN：1097-9751
出版年度：2013
卷号：16
期号：2
页码：100-111
语种：English
出版社：American Society of Exercise Physiologists
摘要：Junior MC, Spagnol AR, Pereira AS, Novais IP, de Castro MR, Anaruma CP, Valgas CP, Luciano E. Response of Creatine Kinase (CK) Levels in Diabetics Wistar Rats After Acute Physical Exercise. JEPonline 2013;16(2):99-111. This study examined the effects of acute exercise on hyperglycemia and kinetic behavior of creatine kinase (CK) in diabetic rats. Wistar rats were distributed into two groups: Exercise Control (C) and Exercise Diabetic (D). Diabetes mellitus was induced by alloxan monohydrate Sigma® (32 mg·kg-1 of body weight). After 7 days, a glucose test was carried out. Animals with values equal to or higher than 200 mg·dL-1 were considered diabetic. After 15 days, both groups were subjected to a single session of 30 min of swimming with a load of 4.5% body weight attached to the dorsal region. Biochemical analyses were performed moments before, immediately after, and at 18 hrs, 24 hrs, 48 hrs, and 96 hrs after aerobic physical exercise through the collection of blood using heparinized capillary. The serum was withdrawn and used for determination of creatine kinase (CK). The CK concentrations were higher at the time immediately after exercise in diabetics (P<0.05). In the control group, there was a tendency of decreased levels of CK after exercise, and at 24 hrs CK levels were lower than at pre exercise. There were significant differences between groups, thus characterizing a higher state of injury in diabetic animals throughout the experiment. Although moderate aerobic exercise caused a reduction of glucose levels in the diabetic rats, there was an increase in the levels of CK that reflects a greater muscular injury.
关键词：Aerobic Exercise;Creatine Kinase;Diabetes Mellitus