文章基本信息

标题：SYNTHESIS AND CHARACTERIZATION OF BIOCONJUGATES OF ANTIGENIC RABIES VIRUS PEPTIDE EPITOPE WITH POLYACRYLIC ACID
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作者：Pelin Pelit Arayici ; Tayfun Acar ; Abel M Maharramov 等
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2017
卷号：26
期号：4
页码：2753-2759
语种：English
出版社：PSP Publishing
摘要：Rabies virus is a certain acute lethal infection and the causative agent of the Central Nervous System. Rabies, the so-called zoonoses, are among the most important diseases spreading by contagion from animals to humans in several ways. Conjugation of antigenic peptides with adjuvant polymers is valuable for developing new generation peptide vaccine. For this purpose, in this study 31D antigenic peptide epitope of rabies virus was conjugated with polyacrylic acid and this conjugates were characterized with high-performance liquid chromatography and gel permeation chromatography. The results suggest that bioconjugation of peptide and polyacrylic acid has a great potential to be developed into an effective vaccine against to rabies virus. For future studies, in vitro and in vivo studies that will be focused on the development of a new generation peptide vaccine are promising.
关键词：Rabies;Synthetic peptide synthesis;Conjugation;Biopolymer;Polymer carriers;Polyacrylic acid