文章基本信息

标题：ANTIOXIDANT AND GENOTOXIC EFFECTS OF CAFFEIC ACID PHENETHYL ESTER (CAPE) IN EXERCISE-INDUCED OXIDATIVE STRESS
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作者：Funda Karabag Coban ; Mustafa Akil ; Recep Liman 等
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2017
卷号：26
期号：4
页码：2684-2688
语种：English
出版社：PSP Publishing
摘要：During the recent years, scientific studies are concentrated upon the possible oxidative stress which is caused by the exhaustive stress. Caffeic acid phenethyl ester (CAPE) is a significant active constituent of propolis, which is originated from honeybee hives. Thanks to its antioxidant, antiproliferative, antiinflammatory, antiviral and antifungal activities, it has received growing attention in several medical and pharmaceutical researches. The purpose of this study was to examine the impacts of CAPE in exercise-induced oxidative stress. Sprague-Dawley Rats (250-300 g) were separated into four groups in this study. The samples of blood and tissues were collected for the examination of biochemical markers and comet assay. Acute swimming exercise led to DNA damage in mononuclear leukocytes and enhanced 8-OhdG levels and also, CAPE significantly (p<0.05) reduced the MDA and 8-OhdG levels. According to findings, it is pointed out that CAPE supplementation reduced DNA damage and enhanced of oxidative stress owing to exhaustive exercise.
关键词：oxidative stress;exhaustive exercise;rat;comet;DNA damage