文章基本信息

标题：Measures on Hidden Markov Models
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作者：Rune B. Lyngsø ; Christian N. S. Pedersen ; Henrik Nielsen 等
期刊名称：BRICS Report Series
印刷版ISSN：0909-0878
出版年度：1999
卷号：6
期号：6
出版社：Aarhus University
摘要：Hidden Markov models were introduced in the beginning of the 1970's as a tool in speech recognition. During the last decade they have been found useful in addressing problems in computational biology such as characterising sequence families, gene finding, structure prediction and phylogenetic analysis. In this paper we propose several measures between hidden Markov models. We give an efficient algorithm that computes the measures for leftright models, e.g. profile hidden Markov models, and discuss how to extend the algorithm to other types of models. We present an experiment using the measures to compare hidden Markov models for three classes of signal peptides.