首页    期刊浏览 2024年12月05日 星期四
登录注册

文章基本信息

  • 标题:Effectiveness of a Glycylcycline Antibiotic for Reducing the Pathogenicity of Superantigen-Producing Methicillin-Resistant Staphylococcus aureus in Burn Wounds
  • 本地全文:下载
  • 作者:Lauren B. Nosanov ; Daniel Y. Jo ; Pranay R. Randad
  • 期刊名称:ePlasty: Open Access Journal of Plastic and Reconstructive Surgery
  • 印刷版ISSN:1937-5719
  • 出版年度:2017
  • 卷号:17
  • 语种:English
  • 出版社:Open Science Co. LLC
  • 摘要:Objective: Burn-injured patients are highly susceptible to infectious complications, which are often associated with increased morbidity and mortality. Rates of antibiotic resistance have increased, and resistant species such as methicillin-resistantStaphylococcus aureusprovide additional challenges in the form of virulence factors. Proteins can disrupt local healing, leading to systemic immune disruption. To optimize outcomes, treatments that reduce pathogenicity must be identified. This study aims to compare a glycylcycline antibiotic—tigecycline—with clindamycin for effectiveness in treating superantigenic methicillin-resistantStaphylococcus aureusin burn wounds.Methods: Sprague-Dawley rats received paired 2 × 2-cm burn wounds, which were subsequently inoculated with known virulence factor–producing methicillin-resistantStaphylococcus aureusor media alone on postinjury day 1. Infected animals received twice-daily tigecycline (high or low dose), twice-daily clindamycin (high or low dose), or saline alone (positive controls). Daily sampling and imaging assessments were performed.Results: Bacterial counts and toxin levels were reduced significantly in antibiotic-treated groups relative to positive controls (P< .001). Results from day 7 showed measurable toxin levels in clindamycin-treated, but not tigecycline-treated, wounds. Imaging analysis revealed a return of wound perfusion in tigecycline-treated animals similar to the sham animals. Transcript analysis using polymerase chain reaction and polymerase chain reaction arrays demonstrated downregulation of gene expression in antibiotic-treated animals as compared with positive controls.Conclusions: Overall, this study supports the use of tigecycline in the treatment of methicillin-resistantStaphylococcus aureus–infected burn wounds. While both protein synthesis inhibitors are effective, tigecycline appears to be superior in controlling toxin levels, enabling better wound healing.
国家哲学社会科学文献中心版权所有