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  • 标题:Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model
  • 本地全文:下载
  • 作者:Kazim Sahin ; Cemal Orhan ; Fatih Akdemir
  • 期刊名称:Food & Nutrition Research
  • 印刷版ISSN:1654-661X
  • 出版年度:2017
  • 卷号:61
  • DOI:10.1080/16546628.2017.1353360
  • 语种:English
  • 出版社:Co-Action Publishing
  • 摘要:ABSTRACTBackground:Mesozeaxanthin (MZ) is a macular carotenoid which has been reported to have a number of pharmacological properties, including the antioxidant, and anticarcinogenic property, and has been stated to decrease the hepatocyte lipid content.Objective:In this study, we investigated the effect of MZ on cardio-metabolic health risk (CMHR) and its probable mechanisms of action in rats fed a high-fat diet (HFD).Design:Rats were randomly divided into four groups consisting of (i) Control, (ii) MZ, (iii) HFD, and (iv) HFD+MZ.Results:MZ treatment increased the antioxidant enzyme activities and helped improve the liver function. The treatment alleviated CMHR and decreased the level of nuclear factor kappa B (NF-κB p65) and tumor necrosis factor-alpha (TNF-α). The levels of hepatic peroxisome proliferator-activated receptor gamma (PPAR-γ), phosphorylated insulin receptor substrate 1 (p-IRS-1), β,β-carotene 9’,10’-oxygenase 2 (BCO2) and nuclear factor erythroid 2-related factor 2 (Nrf2), which decrease in HFD rats, were found to be significantly higher in MZ supplemented animals.Conclusion:MZ has antioxidant and anti-inflammatory properties and can is reported in this study toprotect against fatty liver and cardio-metabolic syndrome, possibly through regulation of PPAR-γ, IRS-1, Nrf2 and NF-κB proteins, in an insulin-resistant rodent model.
  • 关键词:KEYWORDSenHigh-fat dietinsulin resistancelivermesozeaxanthinrats
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