文章基本信息

标题：Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders
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作者：Elisabeth B. Binder
期刊名称：European Journal of Psychotraumatology
印刷版ISSN：2000-8198
电子版ISSN：2000-8066
出版年度：2017
卷号：8
DOI：10.1080/20008198.2017.1412745
语种：English
出版社：Taylor & Francis Group
摘要：Epidemiological studies indicate a combined contribution of genetic and environmental factors, mainly exposure to adverse life events, in the risk for psychiatric disease. Understanding how adverse life events interact with genetic predisposition on the molecular level to shape risk and resilience to psychiatric disorders may yield important insight into disease mechanism. Using the example of the molecular mechanisms of interaction of functional genetic variants within the stress-regulating gene FKBP5 and early adversity, it is delineated how this interaction could contribute to transdiagnostic disease risk via a combined genetic and epigenetic disinhibition of FKBP5 transcription. This knowledge may now allow to develop biomarkers for a transdiagnostic subset of psychiatric patients and to personalize treatment.
关键词：Gene x environment interaction; epigenetics; DNA methylation; early adversity; epigenética; metilación del ADN; estrés; trauma; interacciones gen x entorno; 表观遗传学; DNA 甲基化; 应激; 创伤; 基因 X环境交互