文章基本信息

标题：Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat
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作者：Majda Samih ; Majda Samih ; Pacôme Kouadio N’Go 等
期刊名称：Journal of Behavioral and Brain Science
印刷版ISSN：2160-5866
电子版ISSN：2160-5874
出版年度：2017
卷号：7
期号：10
页码：484-496
DOI：10.4236/jbbs.2017.710034
语种：English
出版社：Scientific Research Pub
摘要：Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.
关键词：Acetylcholinesterase Activity;Neurotoxicity;Dimethoate;Neurobehavior;Organophosphate Insecticides