文章基本信息

标题：Biological correlates of complex posttraumatic stress disorder*state of research and future directions
本地全文：下载
作者：Zoya Marinova ; Andreas Maercker
期刊名称：European Journal of Psychotraumatology
印刷版ISSN：2000-8198
电子版ISSN：2000-8066
出版年度：2015
卷号：6
DOI：10.3402/ejpt.v6.25913
语种：English
出版社：Taylor & Francis Group
摘要：Complex posttraumatic stress disorder (PTSD) presents with clinical features of full or partial PTSD (re-experiencing a traumatic event, avoiding reminders of the event, and a state of hyperarousal) together with symptoms from three additional clusters (problems in emotional regulation, negative self-concept, and problems in interpersonal relations). Complex PTSD is proposed as a new diagnostic entity in ICD-11 and typically occurs after prolonged and complex trauma. Here we shortly review current knowledge regarding the biological correlates of complex PTSD and compare it to the relevant findings in PTSD. Recent studies provide support to the validity of complex PTSD as a separate diagnostic entity; however, data regarding the biological basis of the disorder are still very limited at this time. Further studies focused on complex PTSD biological correlates and replication of the initial findings are needed, including neuroimaging, neurobiochemical, genetic, and epigenetic investigations. Identification of altered biological pathways in complex PTSD may be critical to further understand the pathophysiology and optimize treatment strategies.Keywords: Complex posttraumatic stress disorder; posttraumatic stress disorder; biological correlate; complex trauma; pathophysiologyResponsible Editor: Ruth Lanius, Western University of Canada, Canada.(Published: 16 April 2015)For the abstract or full text in other languages, please see Supplementary files in the column to the right (under ‘Article Tools’ online). Citation: European Journal of Psychotraumatology 2015, 6: 25913 - http://dx.doi.org/10.3402/ejpt.v6.25913
关键词：Complex posttraumatic stress disorder; posttraumatic stress disorder; biological correlate; complex trauma; pathophysiology