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标题：In vitro antimalarial activity of Calophyllum bicolor and hemozoin crystals observed by Transmission Electron Microscope (TEM)
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作者：Jamilah Abbas
期刊名称：MATEC Web of Conferences
电子版ISSN：2261-236X
出版年度：2018
卷号：154
DOI：10.1051/matecconf/201815404004
语种：English
出版社：EDP Sciences
摘要：Objective: In continuation of our antimalarial candidate drug discovery program on Indonesia medicinal plants especially from stem bark ofCalophyllum bicolor. Metode: We extracted of bioactive crude extract with hexane, acetone and methanol from stem bark of Calophyllum bicolor and evaluated their antimalarial activity by using parasitePlasmodium falciparum in vitro. Results:Methanol fraction showed most active and potent antimalarial activity dose dependent inin vitroexperiments with IC50= 0.52 ppb, and hexane fraction showed moderate antimalarial activity, but dose not dependent, while acetone fraction have not antimalarial activity. TEM (Trasmission Electron Microscopy) analysis confirmed a remarkable reduction of hemozoin in the presence of the bioactive fraction. Conclusion: The results suggest that the antimalarial activity ofCalophyllum bicoloris due, methanol fraction showed the bestin vitroantimalarial activity then another fraction.
关键词：enCalophyllum bicolorPlasmodium falciparumin-vitroTEM (Transmition Electron Mecroscope)