文章基本信息

标题：Simultaneous Determination of As, Cu, Cr, Se, Sn, Cd, Sb and Pb Levels in Infant Formulas by ICP-MS after Microwave-Assisted Digestion: Method Validation
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作者：Gianluigi Maria Lo Dico ; Gaetano Cammilleri ; Andrea Macaluso 等
期刊名称：Journal of Environmental & Analytical Toxicology
电子版ISSN：2161-0525
出版年度：2015
卷号：5
期号：6
DOI：10.4172/2161-0525.1000328
语种：English
出版社：OMICS International
摘要：The growing importance of chemical measurements has greatly pressured the development of measures to improve the quality of analytical results and to guarantee quality to the end users. In this work an ICP-MS method was validated for the simultaneous determination of essential trace elements (Chromium, Selenium and Copper) and non-essential toxic elements (Cadmium, Antimony, Arsenic, Tin and Lead) in infant formula available in Sicily. The extraction of samples was performed by a microwave assisted digestion with HNO3 to stabilize these elements. Several parameters have been taken into account and evaluated for the validation of method: selectivity/specificity, trueness by recovery, repeatability and within-laboratory reproducibility at three levels of concentration, instrumental detection limit, limit of determination (LOD), limit of quantification (LOQ), range of linearity, standard measurement uncertainty. Results indicate that this method could be used in the laboratory for the routine determination of these 8 essential and non-essential elements in infant formulas with acceptable analytical performance.
关键词：Validation process; ICP-MS; Infant formula; Heavy metals; Trace elements; Toxic food contamination; Microwave digestion