文章基本信息

标题：Australian Enterococcal Sepsis Outcome Progamme, 2011
本地全文：下载
作者：Geoffrey W Coombs ; Julie C Pearson ; Denise A Daley 等
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2014
卷号：38
期号：3
页码：E247-E252
出版社：Government Department of Health and Ageing
摘要：From 1 January to 31 December 2011, 29 institu- tions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2011 was to deter- mine the proportion of enterococcal bacteraemia isolates in Australia that are antimicrobial resistant, with particular emphasis on susceptibility to ampi- cillin and the glycopeptides, and to characterise the molecular epidemiology of the Enterococcus fae- calis and E. faecium isolates. Of the 1,079 unique episodes of bacteraemia investigated, 95.8% were caused by either E. faecalis (61.0%) or E. faecium (34.8%). Ampicillin resistance was detected in 90.4% of E. faecium but not detected in E. faecalis. Using Clinical and Laboratory Standards Institute breakpoints (CLSI), vancomycin non-susceptibility was reported in 0.6% and 31.4% of E. faecalis and E. faecium respectively and was predomi- nately due to the acquisition of the vanB operon. Approximately 1 in 6 vanB E. faecium isolates however, had an minimum inhibitory concentra- tion at or below the CLSI vancomycin susceptible breakpoint of ≤ 4 mg/L. Overall, 37% of E. fae- cium harboured vanA or vanB genes. Although molecular typing identified 126 E. faecalis pulsed- field gel electrophoresis (PFGE) pulsotypes, more than 50% belonged to 2 pulsotypes that were isolated across Australia. E. faecium consisted of 73 PFGE pulsotypes from which 43 multilocus sequence types were identified. Almost 90% of the E. faecium were identified as clonal complex 17 clones, of which approximately half were charac- terised as sequence type 203, which was isolated Australia-wide. In conclusion, the AESOP 2011 has shown that although polyclonal, enterococcal bacteraemias in Australia are frequently caused by ampicillin-resistant vanB E. faecium.
关键词：antimicrobial resistance surveillance; ; Enterococcus faecium; Enterococcus faecalis; ; vancomycin resistant; bacteraemia