文章基本信息

标题：Investigating effect of water of hydration on active pharmaceutical ingredients in a water-sensitive dosage form
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作者：Monica C. Chuong ; Monica C. Chuong ; Charles J. Kelley 等
期刊名称：Journal of Analytical Science and Technology
电子版ISSN：2093-3371
出版年度：2018
卷号：9
期号：1
页码：1-8
DOI：10.1186/s40543-018-0135-3
语种：English
出版社：Korea Basic Science Institute
摘要：AbstractBackgroundPreparation of mini buccal tablets incorporating either of the Alzheimer’s drugs, rivastigmine tartrate or donepezil hydrochloride, were developed for patients who have difficulty swallowing as a source of effervescence, by pairing the less commonly used malic acid with sodium bicarbonate in an experimentally determined (1:2) stochiometirc ratio.MethodsTo avoid premature reaction of the acid and the base during compounding, the tablet ingredients were mixed in the following order: acid, sweetener, binder, drug, preservative, base, and anti-adherent/lubricant.ResultsAn accelerated thermal stability study at 40 °C and 25% relative humidity showed that the integrity of the effervescent tablets containing rivastigmine tartrate were superior to that of donepezil HCl tablets. FT-IR spectrometry confirmed the presence of water of hydrate in donepezil HCl crystals. This water was absent in the IR after one-month storage at accelerated thermal stability, but was present at room temperature. This behavior was not observed in the tablet made from rivastigmine tartrate powder. Differential scanning calorimetry of donepezil hydrochloride showed two thermal events: the first was associated with the loss of the water, and the second, at much higher temperature, was the melting of theanhydrous drug. Such behavior was not observed in the rivastigmine tartrate powder.ConclusionsHidden water which may function as catalyst to induce premature effervescence during storage.
关键词：Friability;Hardness;Differential scanning calorimetry;Donepezil HCl;Fourier-transform infrared spectroscopy;Malic acid;Rivastigmine tartrate