文章基本信息

标题：An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand Against Avian and Human Influenza Viruses
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作者：Tomonari Tanaka ; Yiting Zhou ; Chihiro Tamoto 等
期刊名称：Journal of Applied Glycoscience
印刷版ISSN：1344-7882
电子版ISSN：1880-7291
出版年度：2017
卷号：64
期号：2
页码：43-48
DOI：10.5458/jag.jag.JAG-2017_003
语种：English
出版社：The Japanese Society of Applied Glycoscience
摘要：A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition. The prepared glycopolymer with pendant 3´-sialyllactose moieties strongly interacted with both avian and human influenza viruses analyzed by the hemagglutination inhibition assay and the quartz crystal microbalance method.
关键词：sialyloligosaccharide;protecting-group-free;click chemistry;RAFT polymerization;glycocluster effect;influenza virus