文章基本信息

标题：Inverse Optimal Impulsive Control Based Treatment of Influenza Infection
本地全文：下载
作者：Gustavo Hernandez-Mejia ; Alma Y. Alanis ; Esteban A. Hernandez-Vargas 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2017
卷号：50
期号：1
页码：12185-12190
DOI：10.1016/j.ifacol.2017.08.2272
语种：English
出版社：Elsevier
摘要：AbstractSeasonal and pandemic influenza A virus (IAV) infections are a cause of severe morbidity and mortality worldwide. In this work, we study the problem of influenza treatment from a control theory perspective. Combined techniques of impulsive control and inverse optimal control are applied to an IAV model. Numerical results show that control-based strategies could improve virological efficacy and at the same time may reduce the drug amount in comparison to current clinical recommendations of pandemic regimens. This work discusses the advantages of theoretical approaches to tackle influenza infections.
关键词：KeywordsInfluenza A VirusPK/PD DynamicsInverse Optimal ControlImpulsive Control