文章基本信息

标题：Role of fluorescence in situ hybridization in the diagnosis of urothelial cancer in asymptomatic hematuria patients
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作者：Peng Wang ; Feng-shuo Jin ; jin Ye 等
期刊名称：Scientific Research and Essays
印刷版ISSN：1992-2248
出版年度：2011
卷号：6
期号：26
页码：5548-5554
DOI：10.5897/SRE11.1126
语种：English
出版社：Academic Journals
摘要：The present study aimed to investigate the feasibility and validity of fluorescence in situ hybridization (FISH) in the diagnosis of urothelial cancer (UC) in asymptomatic hematuria patients. Probes to the pericentromeric regions of chromosomes 3, 7 and 17, and to the 9p21 band were used in FISH at detecting UC in 53 hematuria patients negative on imaging, cystoscopy and cytology but highly suspicious for UC. Among 53 asymptomatic patients with hematuria, 15 were FISH-positive, of whom 13 were followed for 3-12 months. Of these 15 patients, 5 were finally diagnosed with bladder UC and 2 with renal pelvis cancer. Among 38 patients who were FISH-negative, none developed UC during the follow up period. FISH is a significant additional and complementary method for detection of UC in hematuria patients who were negative on cystoscopy and cytology but suspicious for UC.
关键词：Bladder cancer; in situ hybridization; diagnosis