文章基本信息

标题：Effect of tetrandrine on the expression of leptin (LP) and vascular endothelial growth factor (VEGF) in corneal neovascularization of rats
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作者：Guang-li Sun ; Gang Su ; Ming-chang Zhang 等
期刊名称：Scientific Research and Essays
印刷版ISSN：1992-2248
出版年度：2011
卷号：6
期号：23
页码：5008-5013
DOI：10.5897/SRE11.874
语种：English
出版社：Academic Journals
摘要：To investigate the effect of tetrandrine (Tet) on the expression of leptin (LP) and vascular endothelial growth factor (VEGF) in corneal neovascularization (CNV). CNV model was made by alkaline burning. The expressions of LP and VEGF in CNV before and after using Tet were detected slit lamp biomicroscopy, photography and immunohistochemical staining. Immunohistochemistry showed LP was observed in the epithelium, stroma and endothelium of normal rat corneas. The epithelial and stromal layers of the normal rat corneas demonstrated minimal or no VEGF expression. The expression of CNV increased markedly throughout the whole cornea. In the Tet experimental group there were weak (P<0.05) expression levels for LP and VEGF in the corneal stroma. Tet can effectively inhibit the growth of CNV after alkali burns in rats, and reduce the expression of LP and VEGF in CNV.
关键词：Alkali burns; corneal neovascularization; leptin; vascular endothelial growth factor; tetrandrine