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标题：Anti-inflammatory and analgesic activities of the aqueous leaf extract of Agave sisalana in rats
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作者：Marizvikuru Mwale ; Patrick J. Masika ; Joseph Francis 等
期刊名称：Scientific Research and Essays
印刷版ISSN：1992-2248
出版年度：2012
卷号：7
期号：14
页码：1477-1484
DOI：10.5897/SRE11.660
语种：English
出版社：Academic Journals
摘要：Agave sisalana is gaining popularity in controlling gastro-intestinal parasites in chickens and treatment of local inflammatory conditions. However, little is known about its anti-inflammatory and analgesic properties. These properties were determined using the carrageenan, formaldehyde and histamine-induced oedema, as well as formalin, tail flick and acetic acid-induced pain tests. A. sisalana extract was administered per os at 50, 100, 200 and 400 mg/kg body weight of rats. Indomethacin was used as positive control. The 400 mg/kg dose caused 93.4% inflammation inhibition of the carrageenan-induced odema, while 100 mg/kg had 84.9% for the formaldehyde-induced paw oedema. Inflammation inhibition was low (8.1%) for histamine-induced oedema at 400 mg/kg. For tail flick test analgesic activity was low, 55.8 and 0% at 100 and 400 mg/kg, respectively. As for the acetic acid test, analgesic activity was high; 77.2, 81.0, 84.8 and 84.8% for 50, 100, 200 and 400 mg/kg doses, respectively, and for the formalin test it was 66.7 and 100% at 200 mg/kg in phases 1 and 2, respectively. Findings of this study demonstrated that A. sisalana possesses some anti-inflammatory and analgesic properties. Further investigation is necessary to determine the nutritional composition of A. sisalana that may augment its pharmacological properties.
关键词：Medicinal plant; oedematous inhibition; pain relief