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标题：Association of dietary soy with expression of various pro-inflammatory genes in porcine phagocytes
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作者：Georgios Theodorou ; George Papadomichelakis ; Eleni Tsiplakou 等
期刊名称：International Journal of Health, Animal Science and Food Safety
印刷版ISSN：2283-3927
出版年度：2014
卷号：1
期号：1
DOI：10.13130/2283-3927/3382
语种：English
出版社：Department of Health, Animal Science and Food Safety (VESPA)
摘要：Soybean and whey are two common protein sources used in piglet feeding; however, their effects on pro-inflammatory responses remain unclear. The present study investigated the expression of various genes implicated in the activation/deactivation of porcine phagocytes post-weaning. Eighteen piglets were divided into two groups based on the main protein source of their diet; soybean (SB) or whey proteins (WP). Blood phagocytes were isolated at 72 days of age. Expression of urokinase plasminogen activator (u-PA), u-PA receptor (u-PAR), plasminogen activator inhibitors 1 and 2, intercellular adhesion molecule 1 (ICAM-1), inducible NO synthase (iNOS), cyclo-oxygenase-2 and interleukin-10 (IL-10) in activated monocytes and neutrophils (except IL-10) was determined by quantitative PCR. Expression of u-PAR, ICAM-1 and iNOS were lower in both cell types obtained from SB-fed piglets compared to WP-fed piglets. In conclusion, a SB-based diet, compared with a WP diet, is associated with reduced expression of crucial pro-inflammatory genes in porcine phagocytes.
关键词：soy;phagocytes;inflammation