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标题：EFEITO PROZONA NO DIAGNÓSTICO DE SÍFILIS PELO MÉTODO VDRL: EXPERIÊNCIA DE UM SERVIÇO DE REFERÊNCIA NO SUL DO BRASIL
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作者：Danieli Luiza Jung ; Daniela Becker ; Jane Dagmar Pollo Renner 等
期刊名称：Revista de Epidemiologia e Controle de Infecção
印刷版ISSN：2238-3360
出版年度：2014
卷号：4
期号：1
DOI：10.17058/reci.v4i1.3959
语种：Portuguese
出版社：Revista de Epidemiologia e Controle de Infecção
摘要：Backgound and Objectives: Syphilis is a systemic infectious disease caused by the spirochete Treponema pallidum. VDRL (Venereal Diseases Research Laboratory) test is the most often used laboratory method for syphilis diagnosis. The prozone effect may occur in 1% to 2% of patients, especially at late stages of syphilis and during pregnancy. The objective of this study was to evaluate the frequency of this effect in analyses performed at Laboratório Regional de Santa Cruz do Sul do Laboratório Central do Rio Grande do Sul, from April to May 2013. Methods: A descriptive study was performed, in which 2018 samples were analyzed by the VDRL method and subsequently, low titers (≤ 1:4) were confirmed by the immunoblot method. Results: A total of 68 (3.37%) samples were positive, of which 49 (72.1%) belonging to women and of these, 38 (77.5%) pregnant women. The VDRL method showed no prozone effect. The 32 samples with titers ≤ 1:4 were confirmed by the treponemal method, resulting in 6 false-positive results, of which 4 were observed in pregnant women. Conclusion: Although not prozone effect was observed in this study, it was concluded that the VDRL method results must be evaluated individually, with the possibility of confirmation through the treponemal test.
其他摘要：Backgound and Objectives: Syphilis is a systemic infectious disease caused by the spirochete Treponema pallidum. VDRL (Venereal Diseases Research Laboratory) test is the most often used laboratory method for syphilis diagnosis. The prozone effect may occur in 1% to 2% of patients, especially at late stages of syphilis and during pregnancy. The objective of this study was to evaluate the frequency of this effect in analyses performed at Laboratório Regional de Santa Cruz do Sul do Laboratório Central do Rio Grande do Sul, from April to May 2013. Methods: A descriptive study was performed, in which 2018 samples were analyzed by the VDRL method and subsequently, low titers (≤ 1:4) were confirmed by the immunoblot method. Results: A total of 68 (3.37%) samples were positive, of which 49 (72.1%) belonging to women and of these, 38 (77.5%) pregnant women. The VDRL method showed no prozone effect. The 32 samples with titers ≤ 1:4 were confirmed by the treponemal method, resulting in 6 false-positive results, of which 4 were observed in pregnant women. Conclusion: Although not prozone effect was observed in this study, it was concluded that the VDRL method results must be evaluated individually, with the possibility of confirmation through the treponemal test.
关键词：Farmácia;Imunologia