文章基本信息

标题：Skeletal muscle, chronic heart failure and the role of the exercise.
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作者：André Katayama Yamada ; Vanessa Azevedo Voltarelli ; Fabrício Azevedo Voltarelli 等
期刊名称：Motriz. Journal of Physical Education. UNESP
印刷版ISSN：1980-6574
出版年度：2009
卷号：15
期号：3
页码：677-686
DOI：10.5016/2079
语种：Portuguese
出版社：UNESP - São Paulo State University
摘要：Patients with chronic heart failure (CHF) show metabolic, hemodynamic and skeletal muscle alterations which decrease the life expectancy and are attributed to several factors. The focus of this review it will be on the questions related to physiological, metabolic, morphological and molecular alterations which affect the muscular system of these patients. Later, it will be discussed how the physical exercise contributes to this syndrome as well as the pharmacological interventions which are in investigation aiming the treatment of the same. Some muscle alterations are already described on the literature. For example, the more predominance of type II fibers, lower oxidative enzymatic activity, muscle atrophy and elevated concentration of cytokines that affect the muscle integrity. Thus, further studies involving cellular and molecular mechanisms of skeletal muscle in order to create strategies for prevention and treatment for patients with CHF are required.
其他摘要：Patients with chronic heart failure (CHF) show metabolic, hemodynamic and skeletal muscle alterations which decrease the life expectancy and are attributed to several factors. The focus of this review it will be on the questions related to physiological, metabolic, morphological and molecular alterations which affect the muscular system of these patients. Later, it will be discussed how the physical exercise contributes to this syndrome as well as the pharmacological interventions which are in investigation aiming the treatment of the same. Some muscle alterations are already described on the literature. For example, the more predominance of type II fibers, lower oxidative enzymatic activity, muscle atrophy and elevated concentration of cytokines that affect the muscle integrity. Thus, further studies involving cellular and molecular mechanisms of skeletal muscle in order to create strategies for prevention and treatment for patients with CHF are required.
关键词：Insuficiência Cardíaca Crônica. Músculo Esquelético. Exercício Físico. Terapias.