文章基本信息

标题：Modeling, sensitivity analysis and parameter identification of a twin screw extruder
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作者：Jonathan Grimard ; Laurent Dewasme ; Justine Thiry 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2016
卷号：49
期号：7
页码：1127-1132
DOI：10.1016/j.ifacol.2016.07.354
语种：English
出版社：Elsevier
摘要：Following the recent success of hot-melt extrusion in the pharmaceutical field, monitoring and control are increasingly applied. In this study, a mathematical model consisting of mass and energy balance partial differential equations is developed and parameters related to material transportation are inferred from experimental data collected from a pilot plant. This data is relative to the output residence time distribution of active product. Parameter identification is complemented by a parametric sensitivity analysis and the computation of confidence intervals. Direct and cross-validation results demonstrate the good predictive capability of the model, which could probably be exploited for model-based control at a next stage.
关键词：Mathematical ModelingPartial differential equationsestimationpharmaceuticalsprocess control