文章基本信息

标题：Control of a Class of Large-Scale Boolean Networks for Biological Systems Using Constant Inputs
本地全文：下载
作者：Jung–Min Yang ; Kwang–Hyun Cho
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2016
卷号：49
期号：26
页码：300-305
DOI：10.1016/j.ifacol.2016.12.143
语种：English
出版社：Elsevier
摘要：Boolean networks can describe dynamics of genetic and cellular networks in a simple and abstract framework. This paper presents a constant control scheme for stabilization of large-scale Boolean networks. A number of state nodes are selected as constant control inputs so that the Boolean network can reach desirable attractors or cycles. Strongly connected components of the Boolean network are considered to reduce the computational cost. A simulation study on the problem of determining combinatorial targeted drugs for desired cellular phenotype is provided.
关键词：Boolean networksstabilizationsemi-tensor product (STP)constant controlsystems biologybiological networks