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标题：Thiosemicarbazide derivative-functionalized carbon nanotube for simultaneous determination of isoprenaline and piroxicam
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作者：Mohammad Mazloum‐Ardakani ; Mohammad Mazloum‐Ardakani ; Hamideh Mohammadian-Sarcheshmeh 等
期刊名称：Journal of Analytical Science and Technology
电子版ISSN：2093-3371
出版年度：2017
卷号：8
期号：1
页码：1-9
DOI：10.1186/s40543-017-0115-z
语种：English
出版社：Korea Basic Science Institute
摘要：Abstract Background Piroxicam (PX) is a nonsteroidal anti-inflammatory drug of the oxicam category that has been known worth as a chemopreventative, anti-tumor agent, for acute and chronic musculoskeletal. To the best of our knowledge, no paper has been published until now reporting the simultaneous electrocatalytic detection of isoprenaline and PX by using any type of modified electrodes. Methods The glassy carbon electrode modified with multiwalled carbon nanotubes chemically modified with (z)-1-(3,4-dihydroxybenzylidene)-2-methylthiosemicarbazide (DBT–CNT/GCE). The electrocatalytic behavior of analytes was examined using cyclic voltammetry (CV), chronoamperometry, and differential pulse voltammetry (DPV) on the modified electrode. Results In order to determine kinetic parameters such as the anodic transfer coefficient (α = 0.47) and the electron transfer rate constant between the nanocomposite and glassy carbon electrode (ks/s = 0.51), cyclic voltammetry was applied. The results represented a linear relationship versus isoprenaline concentrations in the wide range of 0.5–1500.0 μM and a detection limit of 0.35 μM. Furthermore, DPV was applied successfully for the simultaneous determination of isoprenaline and piroxicam. Conclusions This proposed sensor has been successfully applied to determine the IP and PX in blood serum human, which demonstrates that it has excellent potential application for detection of different concentrations of IP and PX.
关键词：Isoprenaline;Piroxicam;Functionalized carbon nanotube;Thiosemicarbazide