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标题：Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys
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作者：Thuy Lam ; Thuy Lam ; Paige L. Williams 等
期刊名称：Environment International
印刷版ISSN：0160-4120
电子版ISSN：1873-6750
出版年度：2014
卷号：73
页码：135-142
DOI：10.1016/j.envint.2014.06.020
语种：English
出版社：Pergamon
摘要：Abstract Background In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent. Objective To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE)] with male pubertal onset. Methods In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8–9year old boys with measured OCPs were enrolled during 2003–2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. Results In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3mL and P2+ (but not G2+). Mean age at attaining TV>3mL was delayed 3.6 (95% CI: −2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7months (95% CI: −1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1months earlier (95% CI: −5.8, 5.6) for Q2, 4.7months later (95% CI: −1.0, 10.3) for Q3 and 4.6months later (95% CI: −1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p′-DDE concentrations with age of pubertal onset. Conclusion Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche. Highlights • Higher prepubertal serum HCB levels were associated with later male pubertal onset. • Associations were observed at high HCB serum levels relative to other populations. • No significant associations noted with p,p′-DDE or β-HCH and male pubertal onset.
关键词：β-HCH; HCB; Organochlorine pesticides; Male puberty; p,p′-DDE;