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标题：Batch and flow injection spectrophotometric methods for the determination of barbituric acid in aqueous samples via oxidative coupling with 4-aminoantipyrine
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作者：Mohammed Jasim M. Hassan ; Mohammed Jasim M. Hassan ; Wijdan Shakir Khayoon 等
期刊名称：Karbala International Journal of Modern Science
印刷版ISSN：2405-609X
电子版ISSN：2405-609X
出版年度：2015
卷号：1
期号：3
页码：135-141
DOI：10.1016/j.kijoms.2015.10.003
语种：English
出版社：Elsevier
摘要：Abstract A batch and flow injection (FI) spectrophotometric methods are described for the determination of barbituric acid in aqueous and urine samples. The method is based on the oxidative coupling reaction of barbituric acid with 4-aminoantipyrine and potassium iodate to form purple water soluble stable product at λ 510 nm. Good linearity for both methods was obtained ranging from 2 to 60 μg mL−1, 5–100 μg mL−1 for batch and FI techniques, respectively. The limit of detection (signal/noise = 3) of 0.45 μg mL−1 for batch method and 0.48 μg mL−1 for FI analysis was obtained. The proposed methods were applied successfully for the determination of barbituric acid in tap water, river water, and urine samples with good recoveries of 99.92% and 100.67% for batch and FI method, respectively.
关键词：Barbituric acid; 4-Aminoantipyrine; Flow injection; Spectrophotometry; Oxidative-coupling;