文章基本信息

标题：Triphenylphosphine: An efficient catalyst for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione under thermal conditions
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作者：K. Aswin ; K. Aswin ; S. Sheik Mansoor 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2014
卷号：26
期号：2
页码：141-148
DOI：10.1016/j.jksus.2013.05.004
语种：English
出版社：Elsevier
摘要：Abstract An efficient and direct procedure for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives by condensation of 1,3-diaryl-2-propen-1-ones (chalcones) and thiourea in ethanol at 65°C using triphenylphosphine (PPh3) as a catalyst is reported. The method gave good yields of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives in short reaction times in comparison with earlier methods. The catalyst is recycled without loss of activity. Using non-toxic and inexpensive materials, simple work-up, short reaction times and high yields of the products are the advantages of this method.
关键词：4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione; Triphenylphosphine; 1,3-Diaryl-2-propen-1-one; Chalcones;