文章基本信息

标题：Melamine trisulfonic acid as an efficient catalyst for the synthesis of 2,6-dimethyl-4-substituted-1,4-dihydropyridine-3,5-diethyl/dimethylcarboxylate derivatives via Hantzsch reaction in solvent free condition
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作者：S. Sheik Mansoor ; S. Sheik Mansoor ; K. Aswin 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2013
卷号：25
期号：3
页码：191-199
DOI：10.1016/j.jksus.2013.02.001
语种：English
出版社：Elsevier
摘要：Abstract A facile and highly efficient one-pot synthesis of 1,4-dihydropyridine derivatives (1,4-DHPs) is reported via three component condensation reaction of aldehydes, ethyl acetoacetate or methyl acetoacetate and ammonium acetate using environmentally benign melamine trisulfonic acid (MTSA) as a catalyst in solvent free condition at 60°C. The method presented here is applied to the tenets of green chemistry to the generation of biologically interesting products under solvent-free media that is less expensive and less toxic than those with organic solvents. Also, the catalyst is recyclable and could be reused without significant loss of activity. Even after three runs for the reaction, the catalytic activity of MTSA was almost the same as that of the freshly used catalyst. The method also offers several advantages including high yields and simple work-up procedure.
关键词：Melamine trisulfonic acid; 1,4-Dihydropyridine; Hantzsch reaction; One-pot synthesis; Reusable catalyst;