文章基本信息

标题：Padina boergessenii ameliorates carbon tetrachloride induced nephrotoxicity in Wistar rats
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作者：Rajamani Karthikeyan ; Rajamani Karthikeyan ; P. Anantharaman 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2012
卷号：24
期号：3
页码：227-232
DOI：10.1016/j.jksus.2011.03.002
语种：English
出版社：Elsevier
摘要：Abstract This research investigates the ameliorative effect of brown alga Padina boergessenii against CCl4-induced nephrotoxicity in rats. Twenty-four Wistar albino rats were divided into four groups as follows: control group (saline), CCl4 group, CCl4+ P. boergessenii extract group and P. boergessenii extract alone group. At the end of the experimental period, the animals are sacrificed and tissue samples (kidney) were collected. CCl4 at a dose of 2mL/kg, administered subcutaneously, produced significantly decreased activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT). Histopathological examinations showed massive centrilobular necrosis and fat accumulation in CCl4-induced animals. In the protective test, especially in animals pretreated with P. boergessenii (150mg/kg) extract, there was a significant increase in antioxidant enzyme levels although there was no sign of abnormality in the kidney of rats pretreated with extract as evidenced by histopathological sections against CCl4-induced decrease of lipid peroxidation (TBARS). The ameliorative effect may be due to the presence of various bioactive compounds in alga. These results suggest that an extract of P. boergessenii is able to significantly alleviate the nephrotoxicity induced by CCl4 in Wistar rats.
关键词：Padina boergessenii ; CCl4; Nephrotoxicity; Antioxidant;