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标题：Electrochemical oxidation of provitamin B5, d-panthenol and its analysis in spiked human urine
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作者：Deepti S. Nayak ; Deepti S. Nayak ; Nagaraj P. Shetti 等
期刊名称：Journal of Analytical Science and Technology
电子版ISSN：2093-3371
出版年度：2016
卷号：7
期号：1
页码：1-8
DOI：10.1186/s40543-016-0092-7
语种：English
出版社：Korea Basic Science Institute
摘要：Abstract Background The behavior of biomolecules and the advancements in the electrochemical techniques play a tremendous role in the development of voltammetric sensors. Redox reactions of biologically active molecules can be studied by using different voltammetry techniques which guide us to understand the metabolic fact of the targeted drug. In the present work, we describe the electrochemical oxidation of d-panthenol (DP) by using a versatile glassy carbon electrode (GCE). Methods Experimental section was carried out by using cyclic voltammetry and square wave voltammetry. Results Under the optimized conditions (pH 4.2), the square wave voltammetric peak current of d-panthenol increased linearly with its concentration. The detection limit was found to be 5.0 × 10−7 M. The number of protons and electrons involved in the oxidation process were calculated. The heterogeneous rate constant was found to be (3.67 × 103 s−1). Conclusions The method detects the trace level of the analyte with low detection limit which imparts the development of a sensor for selective and sensitive determination of d-panthenol. This sensor was successfully applied to determine the d-panthenol in spiked urine samples.
关键词：;d;-panthenol;Voltammetry;Glassy carbon electrode;Electroanalysis;Oxidation