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标题：El benzo(a)pireno en los alimentos y su relación con el cáncer
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作者：Yuly Nataly Franco Tobón ; Claudia María Ramírez Botero
期刊名称：Perspectivas en Nutrición Humana
印刷版ISSN：2248-454X
出版年度：2013
卷号：15
期号：1
页码：99
语种：Spanish
出版社：Escuela de Nutrición y Dietética, Universidad de Antioquia.
摘要：Background: Benzo[a]pyrene is a polycyclic aromatic hydrocarbon which has been related with adverse health outcomes. Food is a source of benzo[a]pyrene; which is produced during industrial processing or cooking. Objective: To review information about benzo(a)pyrene formation in food, biological activation, association with cancer, food content and regulation of benzo(a)pyrene content in human food. Methods: A literature search from national and international scientific databases was developed. Results: benzo[a]pyrene ingested is absorbed by the intestine metabolized and activated, predominantly, by the liver. Animal studies have associated benzo[a]pyrene with esophagus, stomach, intestine, skin, bladder, lung, and liver cancer. Benzo[a]pyrene is potentially toxic to the fetus, due to it passes trough placenta. Benzo[a]pyrene amounts in some foods exceed the maximum level allowed by the European Commission; which periodically updates legislation on this topic. In Colombia there is not regulation about benzo[a]pyrene. Conclusion: benzo[a]pyrene in food generates compounds that may be associated with cancer, mainly gastrointestinal cancer. The European Commission regularly updates regulation about benzo[a]pyrene content in foods. Colombia does not have regulation on this topic.
其他摘要：Background: Benzo[a]pyrene is a polycyclic aromatic hydrocarbon which has been related with adverse health outcomes. Food is a source of benzo[a]pyrene; which is produced during industrial processing or cooking. Objective: To review information about benzo(a)pyrene formation in food, biological activation, association with cancer, food content and regulation of benzo(a)pyrene content in human food. Methods: A literature search from national and international scientific databases was developed. Results: benzo[a]pyrene ingested is absorbed by the intestine metabolized and activated, predominantly, by the liver. Animal studies have associated benzo[a]pyrene with esophagus, stomach, intestine, skin, bladder, lung, and liver cancer. Benzo[a]pyrene is potentially toxic to the fetus, due to it passes trough placenta. Benzo[a]pyrene amounts in some foods exceed the maximum level allowed by the European Commission; which periodically updates legislation on this topic. In Colombia there is not regulation about benzo[a]pyrene. Conclusion: benzo[a]pyrene in food generates compounds that may be associated with cancer, mainly gastrointestinal cancer. The European Commission regularly updates regulation about benzo[a]pyrene content in foods. Colombia does not have regulation on this topic.
关键词：benzo[a]pyrene; food; anticarcinogenic agents; xenobiotics; carcinogenic; genotoxic; mutagenic; polycyclic hydrocarbons; aromatic;benzo[a]pireno; cáncer; alimentos; xenobióticos; carcinogénicos; genotóxicos; mutagénicos; hidrocarburo aromático policíclico
其他关键词：benzo[a]pyrene, food, anticarcinogenic agents, xenobiotics, carcinogenic, genotoxic, mutagenic, polycyclic hydrocarbons, aromatic