文章基本信息

标题：ANTIBACTERIAL ACTIVITIES OF BACTERIAL SYMBIONTS OF SOFT CORAL Sinularia sp. AGAINST TUBERCULOSIS BACTERIA
本地全文：下载
作者：S. Sulistiyani ; Sri Achadi Nugraheni ; Ocky Karna Radjasa 等
期刊名称：JOURNAL OF COASTAL DEVELOPMENT
印刷版ISSN：1410-5217
出版年度：2010
卷号：14
期号：1
页码：45-50
语种：English
出版社：JOURNAL OF COASTAL DEVELOPMENT
摘要：Tuberculosis (TB) is caused by Mycobacterium tuberculosis. Although TB is a curable disease, it continues to be one of the most important infectious causes of death worldwide. Indonesia ranks 3rd on the list of TB high burden countries in the world with 86,000 cases deaths and the Multi Drug Resistant Tuberculosis (MDR TB) estimated cases in Indonesia is 10,000. This research was aimed to isolate and characterize of soft coral Sinularia sp.-associated bacteria having antibacterial activity against Tuberculosis bacteria. There were 109 isolates collected from Sinularia sp. Two isolates from Sinularia sp.-associated bacteria, SC4TGZ3 and SC4TGZ4 were successfully screened for antibacterial against Tuberculosis bacteria. SC4TGZ3 was found to inhibit the growth of MDR TB strain HE, MDR TB strain SR and H37Rv. Whereas, SC4TGZ4 was found to inhibit the growth of MDR TB strain HE. Based on PCR amplification 16S rDNA softcoral bacateria were identified as follows: SC4TGZ3 was closely related to Pseudovibrio sp. and SC4TGZ4 was closely related to Alpha proteobacterium sp.
关键词：Mycobacterium tuberculosis;Sinularia sp.;MDR-TB;Antibacterial activities;associated bacteria