文章基本信息

标题：GROWTH INHIBITION OF MEDICALLY ANTIBIOTIC RESISTANT BACTERIA BY SPONGE-ASSOCIATED BACTERIA
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作者：Ocky Karna Radjasa
期刊名称：JOURNAL OF COASTAL DEVELOPMENT
印刷版ISSN：1410-5217
出版年度：2008
卷号：11
期号：2
页码：75-80
语种：English
出版社：JOURNAL OF COASTAL DEVELOPMENT
摘要：The improper and uncontrolled uses of antibiotics against pathogenic bacteria have resulted in the occurrence of Multi Drugs Resistant bacteria. There is now an urgency to find alternative antibiotics to combat these bacteria. The metabolites from microorganisms are a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Therefore, there is a shift in the search for secondary metabolites from terrestrial to marine environment. Sponge-associated microorganisms are among of the most interesting and promising marine natural product sources, which produce polyketide and non ribosomal peptide products with various biological activities. In this study, marine bacteria were isolated from sponge Haliclona sp. collected from North Java Sea, and were screened for antibacterial activity against MDR strains. One out of 32 bacterial isolates were successfully screened and were found to be active against MDR strains, strain Escherichia coli and strain Proteus sp., respectively. These active isolates were also capable of amplifying NRPS gene fragments necessary for the biosynthesis of non ribosomal peptides. The identification results revealed that the active isolates are Arthrobacter sp.
关键词：antibacterial, marine bacteria, sponge Haliclona sp., MDR