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标题：The Synergism of Diltiazem and Nifedipine in their Antihypertensive Functions in the Animal Model and the Case of Coadministration of Ketotifen Fumerate and Potassium Nitrate with them
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作者：Md Shah Amran ; Md Rahatuzzamn ; Md Amjad Hossain 等
期刊名称：Journal of Bio-Science
印刷版ISSN：1023-8654
出版年度：2006
卷号：14
期号：0
页码：61-67
DOI：10.3329/jbs.v14i0.444
语种：English
出版社：Institute of Biological Sciences, Rajshahi University
摘要：An in vivo study has been carried out to evaluate the synergism of diltiazem and nifedipine on the antihypertensive activity and the effect of ketotifen fumerate and potassium nitrate on this phenomenon of synergism in rabbit. It has been found that the lowering of blood pressure by concurrent administration of diltiazem and nifedipine was not equal to the sum of lowering of blood pressure by individual drug. Concurrent administration of ketotifen fumerate and potassium nitrate with diltiazem or with nifedipine did not make a significant change on the antihypertensive activity of diltiazem or nifedipine. Further considerations and monitoring are to be practiced during concurrent therapy of diltiazem and nifedipine to avoid untoward pharmacological and therapeutic actions related to druginteractions but coadministration of ketotifen fumerate and potassium nitrate with either diltiazem or nifedipine might be regarded as safe and effective. Keywords: in vivo , antihypertensive activity, nifedipine, diltiazem, ketotifen fumerate, potassium nitrate, coadministration. J. bio-sci. 14: 61-67, 2006
关键词：in vivo;antihypertensive activity;nifedipine;diltiazem;ketotifen fumerate;potassium nitrate;coadministration