文章基本信息

标题：Early Hepatotoxicity of Methotrexate in Rheumatoid Arthritis
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作者：M Shakila Parvin ; Mamun Ur Rashid ; ARM Saifuddin Ekram 等
期刊名称：TAJ: Journal of Teachers Association
印刷版ISSN：1019-8555
出版年度：2008
卷号：21
期号：2
页码：147-151
DOI：10.3329/taj.v21i2.3795
语种：English
出版社：Teachers Association of Rajshahi Medical College
摘要：The present study was undertaken to evaluate methotrexate induced early hepatotoxicity in rheumatoid arthritis patients. This study was carried out on ARA criteria fulfilling 35 diagnosed rheumatoid arthritis patients of either gender, aged 20-60 years, presented in Medicine Department of Rajshahi Medical College Hospital, Rajshahi from July 2007 to June 2008. Patients with normal liver function tests and HBsAg and anti-HCV negative cases were given oral Methotrexate (10-25mg/week) for 3 months. Baseline level of SGPT, serum bilirubin and prothrombin time was 10.07±0.32u/l, 0.59±0.03mg/dl and 12.97±0.34 seconds respectively. After 3 months of methotrexate therapy, level of SGPT, serum bilirubin and prothrombin time was found to be 12.60±1.16 u/l, 0.70±0.06mg/dl and 13.87±0.45 seconds respectively. During methotrexate therapy SGPT level changed significantly (p<0.05). Change of serum bilirubin and prothrombin time was not significant. doi: 10.3329/taj.v21i2.3795 TAJ 2008; 21(2): 147-151
关键词：Rheumatoid arthritis