文章基本信息

标题：Induksi Polifenol Mahkota Dewa dan Apoptosis Sel Kanker Paru Mencit Strain Balb/C: Analisis pada Up-Regulation Bax dan Down-Regulation Bcl-2
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作者：Theopilus W Watuguly ; Tjahjono Tjahjono ; Martha Kaihena 等
期刊名称：MEDIA MEDIKA INDONESIANA
印刷版ISSN：0126-1762
出版年度：2012
卷号：46
期号：1
页码：33-43
语种：English
出版社：MEDIA MEDIKA INDONESIANA
摘要：Mahkota Dewa polyphenol induction and apoptosis cell lung cancer in Balb/c strain mice analysis on up-regulation bax and downregulation Bcl-2 Background: This research is aimed to prove the role of Mahkota Dewa polyphenol in the up-regulation Bax and down-regulation in strain Balb/c mice which inducted with benzo(a)pyrene (BaP). Method: Post test control group design with 30 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice condition. All mice inducted with BaP and then randomized into 2 groups, which were the control group and the treatment group (polyphenol 50mg). The development of the lung carcinogenesis was observed by tissue surgery in the 8th, 17th and 26th week. The data collected include expression examination Bax and Bcl-2. The data analysis was conducted by Kruskal-Wallis, Mann-Whitney and correlation test of Spearman's with significance degree of p
关键词：Polyphenol, Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl), protein Bax, protein Bcl-2, strain Balb/c mice, benzo(a)pyrene (BaP)