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标题：Dysregulation in cortical reactivity to emotional faces in PTSD patients with high dissociation symptoms
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作者：Aleksandra Klimova ; Richard A. Bryant ; Leanne M. Williams 等
期刊名称：European Journal of Psychotraumatology
印刷版ISSN：2000-8198
电子版ISSN：2000-8066
出版年度：2013
卷号：4
DOI：10.3402/ejpt.v4i0.20430
语种：English
出版社：Taylor & Francis Group
摘要：Background: Predominant dissociation in posttraumatic stress disorder (PTSD) is characterized by restricted affective responses to positive stimuli. To date, no studies have examined neural responses to a range of emotional expressions in PTSD with high dissociative symptoms.Objective: This study tested the hypothesis that PTSD patients with high dissociative symptoms will display increased event-related potential (ERP) amplitudes in early components (N1, P1) to threatening faces (angry, fearful), and reduced later ERP amplitudes (Vertex Positive Potential (VPP), P3) to happy faces compared to PTSD patients with low dissociative symptoms.Methods: Thirty-nine civilians with PTSD were classified as high dissociative (n=16) or low dissociative (n=23) according to their responses on the Clinician Administered Dissociative States Scale. ERPs were recorded, whilst participants viewed emotional (happy, angry, fear) and neutral facial expressions in a passive viewing task.Results: High dissociative PTSD patients displayed significantly increased N120 amplitude to the majority of facial expressions (neutral, happy, and angry) compared to low dissociative PTSD patients under conscious and preconscious conditions. The high dissociative PTSD group had significantly reduced VPP amplitude to happy faces in the conscious condition.Conclusion: High dissociative PTSD patients displayed increased early (preconscious) cortical responses to emotional stimuli, and specific reductions to happy facial expressions in later (conscious), face-specific components compared to low dissociative PTSD patients. Dissociation in PTSD may act to increase initial pre-attentive processing of affective stimuli, and specifically reduce cortical reactivity to happy faces when consciously processing these stimuli.Keywords: posttraumatic stress disorder (PTSD); dissociation; ERPs; faces; emotion(Published: 4 September 2013)For the abstract or full text in other languages, please see Supplementary files in the column to the right (under Article Tools)Citation: European Journal of Psychotraumatology 2013, 4: 20430 - http://dx.doi.org/10.3402/ejpt.v4i0.20430
关键词：posttraumatic stress disorder (PTSD); dissociation; ERPs; faces; emotion