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标题：Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review
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作者：Rianne A. de Kleine ; Barbara O. Rothbaum ; Agnes van Minnen 等
期刊名称：European Journal of Psychotraumatology
印刷版ISSN：2000-8198
电子版ISSN：2000-8066
出版年度：2013
卷号：4
DOI：10.3402/ejpt.v4i0.21626
语种：English
出版社：Taylor & Francis Group
摘要：There is a good amount of evidence that exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). Notwithstanding its efficacy, there is room for improvement, since a large proportion of patients does not benefit from treatment. Recently, an interesting new direction in the improvement of exposure therapy efficacy for PTSD emerged. Basic research found evidence of the pharmacological enhancement of the underlying learning and memory processes of exposure therapy. The current review aims to give an overview of clinical studies on pharmacological enhancement of exposure-based treatment for PTSD. The working mechanisms, efficacy studies in PTSD patients, and clinical utility of four different pharmacological enhancers will be discussed: D-cycloserine, MDMA, hydrocortisone, and propranolol.Keywords: Posttraumatic stress disorder; cognitive enhancers; treatment efficacy; exposure therapy(Published: 17 October 2013)For the abstract or full text in other languages, please see Supplementary files in the column to the right (under Article Tools)Citation: European Journal of Psychotraumatology 2013, 4: 21626 - http://dx.doi.org/10.3402/ejpt.v4i0.21626
关键词：Posttraumatic stress disorder; cognitive enhancers; treatment efficacy; exposure therapy